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6BIO
Cat No.
CEI-0951
Description
Scientific Background Potent and selective inhibitor of glycogen synthase kinase-3 (GSK-3) IC50=5 nM. The first pharmacological agent shown to maintain self-renewal in human and mouse embryonic stem cells. Promotes proliferation in mammalian cardiomyocytes. A potent inhibitor of malignant lymphoid cell proliferation.
Abbr
6BIO(GSK3)
Alias
(2'Z, 3'E)-6-Bromoindirubin-3'-oxime
Appearance
Purple powder
Product Overview
GSK3 inhibitor
CAS No.
667463-62-9
Molecular Weight
356.2
Purity
98% (TLC: 5% CH3OH3 in CH2Cl2, Rf=0.43); NMR (Conforms)
Synonyms
(2'Z,3'E)-6-Bromoindirubin-3'-oxime
Targets
GSK3
Molecular Formula
C16H10BrN3O2
Melting Point
263-265ºC
Solubility
Soluble in DMSO (15 mg/ml); or Ethanol (4 mg/ml, warm)
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