Description
5-Hydroxydecanoate Na (5-HD) is a substrate for mitochondrial outer membrane ACSL (acyl-CoA synthetase) that inhibits ATP-sensitive K+ channels. In neuronal type K sensitive ATP channel currents, 5-Hydroxydecanoate Na diminished the produced activation of the channels by PKG. On perfused rat hearts, 5-Hydroxydecanoate Na has shown the ability to inhibit the toxicity of 6-hyrdoxydopamine on dopaminergic neurons. 5-Hydroxydecanoate Na has displayed a lack of activity in inhibiting oxygen consuming mitochondria derived from skeletal muscle.
Applications
An inhibitor of ATP-sensitive K+ channels
Synonyms
5-Hydroxycapric acid sodium salt; 5-Hydroxydecanoic acid sodium salt
Molecular Formula
C10H19O3•Na
Solubility
Soluble in water (25 mg/ml), and ethanol (10 mg/ml).
Substrates
β-D-galactosidase
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