Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid
Cat No.
NATZ-099
Description
4-Methylumbelliferyl-α-L-iduronide (free acid) is a fluorogenic substrate for α-L-iduronidase, an enzyme found in cell lysosomes that is involved in the degradation of glycosaminoglycans such as dermatan sulfate and heparin sulfate. 4-Methylumbelliferyl-α-L-iduronide is cleaved by α-L-iduronidase to release the fluorescent moiety 4-methylumbelliferyl (4-MU). 4-MU fluorescence is pH-dependent with excitation maxima of 320 and 360 nm at low (1.97-6.72) and high (7.12-10.3) pH, respectively, and an emission maximum ranging from 445 to 455 nM, increasing as pH decreases. This substrate is used in assays that measure the activity of α-L-iduronidase, which is commonly deficient in a type of lysosomal storage disease called mucopolysaccharidosis.
Form
A crystalline solid
CAS No.
66966-09-4
Molecular Weight
352.3
Purity
90%
Storage
-20°C
Synonyms
4-Methylumbelliferyl-α-L-Idopyranosiduronic Acid
4-MU-α-IdoA
MU-α-IdoA
4-MU-α-IdoA
MU-α-IdoA
Molecular Formula
C16H16O9
Download
Download Datasheet