Description
A P450 heme-thiolate protein that is found in liver microsomes and in ciliary non-pigmented epithelium. The enzyme is specific for (24S)-cholest-5-ene-3β,24-diol, which is formed mostly in the brain by EC 1.14.14.25, cholesterol 24-hydroxylase. The direct electron donor to the enzyme is EC 1.6.2.4, NADPH-hemoprotein reductase.
Form
Liquid or lyophilized powder
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
24-hydroxycholesterol 7α-monooxygenase; CYP39A1; CYP39A1 oxysterol 7α-hydroxylase
Reaction
(24S)-cholest-5-ene-3β,24-diol + [reduced NADPH-hemoprotein reductase] + O2 = (24S)-cholest-5-ene-3β,7α,24-triol + [oxidized NADPH-hemoprotein reductase] + H2O
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
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