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17-AAG
Cat No.
CEI-0534
Description
A semi-synthetic derivative of Geldanamycin that displays greater stability and lower in vivo toxicity compared to Geldanamycin. Binds to Heat shock protein 90 (Hsp90) (EC₅₀ = 7.2 µM) in a manner similar to geldanamycin. Exhibits 100-fold higher affinity for tumor-derived Hsp90 over normal cells. Also inhibits Akt activation and HER2 expression in tumor cells.
Alias
Telatinib; 17-(Allylamino)geldanamycin; Tanespimycin
Appearance
White solid
Product Overview
A Hsp90 inhibitor
CAS No.
75747-14-7
Molecular Weight
283.92
Purity
>97% by TLC
Storage
-20 centigrade
Synonyms
Telatinib;17-(Allylamino)geldanamycin; Tanespimycin
Targets
HSP90
Molecular Formula
C₃₁H₄₃N₃O₈
Chemical Name
17-(Allylamino)-17-demethoxygeldanamycin
Solubility
DMSO (25 mg/ml)
Shipping Conditions
Gel pack
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