Description
Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin, β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC50 =3.6 µM).
Product Overview
A DNA topoisomerase I inhibitor and a histone demethylase (HDM) inhibitor
Molecular Formula
C15H14O3
Chemical Name
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Solubility
DMSO (~ 25 mg/ml)
Shipping Conditions
Gel pack
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