Products
Online Inquiry
Our Products Cannot Be Used As Medicines Directly For Personal Use.
Welcome! For price inquiries, please feel free to contact us through the form on the left side. We will get back to you as soon as possible.
β-Lapachone
Cat No.
CEI-0468
Description
Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin, β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC50 =3.6 µM).
Appearance
White solid
Product Overview
A DNA topoisomerase I inhibitor and a histone demethylase (HDM) inhibitor
CAS No.
4707-32-8
Molecular Weight
435.52
Purity
>98% by TLC
Storage
-20 centigrade
Targets
TOP1MT
Molecular Formula
C15H14O3
Chemical Name
3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione
Solubility
DMSO (~ 25 mg/ml)
Shipping Conditions
Gel pack
Download
Download Datasheet