Description
α-Bungarotoxin is a snake venom-derived toxin that irreversibly binds nicotinic acetylcholine receptors (Ki = ~ 2.5 µM in rat) present in skeletal muscle, blocking action of acetylcholine at the postsynaptic membrane and leading to paralysis. It has been widely used to characterize activity at the neuromuscular junction, which has numerous applications in neuroscience research.
Appearance
A white to off-white solid
Targets
α7, α1/β1/γ/δ nAChR, GABA(A) receptor subtypes
Molecular Formula
C338H529N97O105S11
Solubility
Soluble in aqueous buffers
Shipping Conditions
Room temperature in continental US; may vary elsewhere
Amino Acid Sequence
IVCHTTATSPISAVTCPPGENLCYRKMWCDAFCSSRGKVVELGCAATCPSKKPYEEVTCCSTDKCNPHPKQRPG
Download Datasheet