Enzymes for Research, Diagnostic and Industrial Use
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Catalog | Product Name | EC No. | CAS No. | Source | Price |
---|---|---|---|---|---|
EXWM-4035 | dipeptidase E | EC 3.4.13.21 | Inquiry |
α-Aspartyl dipeptidase E (ASPE) is an enzyme that plays a crucial role in various biological processes. We aim to provide a comprehensive overview of ASPE, including its structure, functions, clinical significance, and other relevant information.
ASPE is an intracellular enzyme found mainly in the cytoplasm and lysosomes of various tissues including the brain, liver, kidney, and lung. It is a homodimeric protein consisting of two identical subunits, each containing 346 amino acids. The enzyme belongs to the M20 family of metallopeptidases and requires divalent metal ions such as zinc for its catalytic activity.
The activity of ASPE can be modulated by a variety of factors including pH, temperature and the presence of divalent metal ions. In addition, a number of compounds and inhibitors have been identified as modulators of ASPE activity. These include synthetic peptidomimetics and natural products that enhance or inhibit ASPE activity. The search for ASPE modulators may open new avenues for the treatment of diseases associated with ASPE dysregulation.
α-Aspartyl dipeptidase E (ASPE) is a multifunctional enzyme involved in peptide degradation, neuropeptide metabolism and amino acid homeostasis. Its role in numerous physiological and pathological processes highlights its clinical significance. Dysregulation of ASPE has been associated with neurological disorders and cancer, suggesting its potential as a therapeutic target and biomarker. In order to fully understand the importance of ASPE in human health and disease, further research into the mechanism of action and potential therapeutic applications of ASPE is necessary.