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xanthine dehydrogenase
Cat No.
EXWM-1082
Description
Acts on a variety of purines and aldehydes, including hypoxanthine. The mammalian enzyme can also convert all-trans retinol to all-trans-retinoate, while the substrate is bound to a retinoid-binding protein. The enzyme from eukaryotes contains [2Fe-2S], FAD and a molybdenum centre. The mammalian enzyme predominantly exists as the NAD-dependent dehydrogenase (EC 1.17.1.4). During purification the enzyme is largely converted to an O2-dependent form, xanthine oxidase (EC 1.17.3.2). The conversion can be triggered by several mechanisms, including the oxidation of cysteine thiols to form disulfide bonds [which can be catalysed by EC 1.8.4.7, enzyme-thiol transhydrogenase (glutathione-disulfide) in the presence of glutathione disulfide] or limited proteolysis, which results in irreversible conversion. The conversion can also occur in vivo.
Form
Liquid or lyophilized powder
Enzyme Commission Number
CAS No.
9054-84-6
Storage
Store it at +4 ºC for short term. For long term storage, store it at -20 ºC～-80 ºC.
Synonyms
NAD+-xanthine dehydrogenase; xanthine-NAD+ oxidoreductase; xanthine/NAD+ oxidoreductase; xanthine oxidoreductase
Reaction
xanthine + NAD+ + H2O = urate + NADH + H+
Notes
This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
Download
Download Datasheet| Catalog | Product Name | EC No. | CAS No. | Source | Price |
|---|---|---|---|---|---|
| NATE-1064 | Native Xanthine dehydrogenase from Microorganism | EC 1.17.1.4 | 9054-84-6 | Microorganism | Inquiry |
| NATE-1065 | Native Xanthine Dehydrogenase from Bovine milk | EC 1.17.1.4 | 9054-84-6 | Bovine milk | Inquiry |