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Reserpine
Cat No.
CEI-0378
Description
Reserpine
CAS No.
50-55-5
Molecular Weight
608.68
Purity
>99%
Storage
2 years at -20 centigrade
Targets
Multidrug efflux pumps
Molecular Formula
C33H40N2O9
Chemical Name
11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
Solubility
DMSO 13 mg/mL, Water
In vitro
Reserpine is an indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms, although because of the development of better drugs for these purposes and because of its numerous side-effects, it is rarely used today. Reserpine acts by blocking the vesicular monoamine transporter VMAT, which normally transports free norepinephrine, serotonin, and dopamine from the cytoplasm of the presynaptic nerve into vesicles for subsequent release into the synaptic cleft. The unprotected neurotransmitters are then metabolized by MAO and therefore never reach the synapse.
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