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Phlorizin (Phloridzin)
Cat No.
CEI-0374
Description
Phlorizin (PZ) could inhibit glucose transport. Phlorizin induces immediate and sustains glycosuria and osmotic diuresisin a rat model of PKD. Phlorizin dose dependently inhibits MAP kinase in cultured tubular epithelial cells from Cy/+ rats. Long-term treatment with phlorizin significantly inhibits cystic disease progression in a rat model of PKD. Phlorizin significantly decreases body weight gain and the levels of serum fasting blood glucose (FBG), triglycerides (TG), total cholesterol (TC), and advanced glycation end products (AGEs). Phlorizin may prevent the development of diabetic cardiomyopathy by regulating the expression of key proteins involved in cardiac lipid metabolism, mitochondrial function, and cardiomyopathy. Phlorizin treatment significantly reduces fasting blood glucose and levels of advanced glycation end products (p Phlorizin protects the db/db mice from diabetic macrovascular complications, attributed to the decreasing of blood glucose and AGEs level, and its antioxidant potential. In diabetic rats, phlorizin treatment decreases hyperglycemia and prevents development of hypertension, decreased SGLT2 activity in BBMV but did not modify SGLT2 expression.
CAS No.
60-81-1
Molecular Weight
436.41
Purity
>98%
Storage
2 years -20centigrade Powder
Targets
SGLT
Molecular Formula
C21H24O10
Chemical Name
Phlorhizin, Phlorizoside
Solubility
DMSO 87 mg/mL,Water
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