Chemical Name
Benzenepropanoic acid, beta-(benzoylamino)-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-6,12b-bis(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,11-dihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano-1H-cyclodeca[3,4]ben
In vitro
As an anti-microtubule agent, paclitaxel can inhibit proliferation of human endothelial cells with IC50 from 1 pM to 100 pM. Cells began accumulating in G2/M after exposure to paclitaxel. Paclitaxel inhibits the progression of mitotic cells to G1 phase. Paclitaxel-treated cells eventually reform nuclear membranes around individual or clusters of chromosomes, revert to G1 phase cells containing 4C DNA, and enter S phase, resulting in cells with as much as 8C DNA content.
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