Description
Epoxide hydrolase (also known as epoxide hydratase) functions in detoxification during drug metabolism. It converts epoxides to trans-dihydrodiols, which can be conjugated and excreted from the body. Epoxides result from the degradation of aromatic compounds. Deficiency in this enzyme in patients receiving aromatic-type anti-epileptic drugs such as phenytoin is reported to lead to DRESS syndrome. Epoxides are significant as cytochrome P450 oxidase metabolites of unsaturated carbon-carbon bonds, but are also mutagenic. Epoxide hydrolase is present in large quantity on endoplasmic reticulum.
Abbr
mEH, Native (Rhodococcus rhodochrous)
Source
Rhodococcus rhodochrous
Form
lyophilized powder, beige
Enzyme Commission Number
EC 3.3.2.3
Unit Definition
1 U corresponds to the amount of enzymes which hydrolizes 1 μmol (S)-NEPC [(2S,3S)-trans-3-phenyl-2-oxiranylmethyl-4-nitrophenyl carbonate] per minute at pH 8.0 and 25°C
Warnings
Asymmetric hydrolysis of epoxides to optically active diols
Synonyms
EC 3.3.2.3; epoxide hydratase; epoxide hydratase (ambiguous); microsomal epoxide hydratase; epoxide hydrase; microsomal epoxide hydrase; arene-oxide hydratase (ambiguous); benzo[a]pyrene-4,5-oxide hydratase; benzo (a)pyrene-4,5-epoxide hydratase; aryl epoxide hydrase (ambiguous); cis-epoxide hydrolase; mEH; 9048-63-9
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