Description
Glucose 6-phosphatase (EC 3.1.3.9, G6Pase) is an enzyme that hydrolyzes glucose-6-phosphate, resulting in the creation of a phosphate group and free glucose. Glucose is then exported from the cell via glucose transporter membrane proteins. This catalysis completes the final step in gluconeogenesis and glycogenolysis and therefore plays a key role in the homeostatic regulation of blood glucose levels.
Abbr
G6Pase, Native (Rabbit)
Applications
Glucose-6-Phosphatase was used to study the effects of Clausena anisata (Wild hook leaf) extracts on selected diabetes-related metabolizing enzymes.
Enzyme Commission Number
EC 3.1.3.9
Activity
> 0.05 units/mg protein
Purity
Protein ~30 % (balance mostly sucrose)
Unit Definition
One unit will release 1.0 μmole of inorganic phosphate from glucose 6-phosphate per min at pH 6.5 at 37°C.
Warnings
It has been reported that glucose-6-phosphatase, inorganic pyrophosphatase, and pyrophosphate glucose phosphotransferase are asseciated with a single protein that catalyzes three different reactions: a) glucose 6-phosphate + H2O → glucose + Pi b) PPi + H2O → 2 Pi c) glucose + PPi or nucleoside-DP or-TP → glucose 6-phosphate + Pi or nucleoside-MP.
Synonyms
EC 3.1.3.9; glucose 6-phosphate phosphatase; G6Pase; 9001-39-2; glucose-6-phosphatase
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