Description
Cathepsin S is a lysosomal cysteine protease found primarily in the spleen and in lung macrophages. Its level is elevated in the brain tissue of those with Alzheimer's disease and Down syndrome. Cathepsin S may function in the processing of amyloid precursor protein to amyloid beta peptides.
Abbr
CTSS, Native (Human)
Applications
Cathepsin S from human spleen has been used in a study to assess the sequence identification, tissue distribution and polymorphism of the porcine cathepsin D (CTSD) Gene. Cathepsin S from human spleen has also been used in a study to investigate a new promising camptothecin analogue-polysaccharide conjugate.
Form
lyophilized powder. Lyophilized from 100 mM sodium acetate, pH 5.5, and 1 mM EDTA.
Enzyme Commission Number
EC 3.4.22.27
Unit Definition
One unit will hydrolyze Z-Val-Val-Arg-NHMec to yield 2 nanomoles of 7-amino-4-mehtylcoumarin in 10 minutes at pH 6.5 at 25°C
Pathway
Adaptive Immune System, organism-specific biosystem; Antigen processing and presentation, organism-specific biosystem; Antigen processing and presentation, conserved biosystem; Antigen processing-Cross presentation, organism-specific biosystem; Class I MHC mediated antigen processing and presentation, organism-specific biosystem; Endosomal/Vacuolar pathway, organism-specific biosystem
Function
cysteine-type endopeptidase activity; peptidase activity
Synonyms
CTSS; cathepsin S; EC 3.4.22.27; FLJ50259; MGC3886
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