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Levofloxacin
Cat No.
CEI-0379
Description
Levofloxacin
Alias
Levaquin, Tavanic
CAS No.
100986-85-4
Molecular Weight
361.37
Purity
>99%
Storage
2 years at -20centigrade Powder
Synonyms
Levaquin, Tavanic
Targets
DNA gyrase
Molecular Formula
C18H20FN3O4
Solubility
DMSO 24 mg/mL, Water 11 mg/mL, Ethanol 21 mg/mL
In vitro
Levofloxacin(Levaquin) is a synthetic fluoroquinolone (fluoroquinolones) antibacterial agent that inhibits the supercoiling activity of bacterial DNA gyrase, halting DNA replication. Levofloxacin inhibits bacterial type II topoisomerases, topoisomerase IV and DNA gyrase. Levofloxacin, like other fluoroquinolones, inhibits the A subunits of DNA gyrase, two subunits encoded by the gyrA gene. This results in strand breakage on a bacterial chromosome, supercoiling, and resealing; DNA replication and transcription is inhibited. [1]
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