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Lactacystin (Synthetic)
Cat No.
CEI-0393
Description
Cell-permeable. A potent and selective inhibitor of the 20 S proteasome. Binds irreversibly to the active site N-terminal threonine residue of the catalytic β-subunit of the 20S proteasome, thereby inhibiting its chymotrypsin and trypsin-like activities. Induces neurite outgrowth in Neuro 2A neuroblastoma cells and has been reported to induce apoptosis in human monoblast U937 cells. Also inhibits NF-kB activation (IC50 = 10 µM).
Appearance
White solid
Product Overview
A proteasome inhibitor
CAS No.
133343-34-7
Molecular Weight
360.43
Purity
>95% by HPLC
Storage
+4 centigrade
Targets
20 S proteasome
Molecular Formula
C₁₅H₂₄N₂O₇S
Solubility
DMSO (10 mg/ml)
Shipping Conditions
RT
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