Description
A cell-permeable hexabromocyclohexane compound that interacts with a solvent-accessible pocket near the activation loop of JAK2 and acts as a specific, reversible, and direct inhibitor of JAK2 autophosphorylation (maximal inhibition at 50 µM in BSC-40 cells overexpressing JAK2). Reduces growth hormone-mediated JAK2 activation in γ2A cells that stably express growth hormone receptor and JAK2. Does not block EGFR autophosphorylation in murine fibroblasts.
Abbr
JAK2 Inhibitor II(JAK2)
Storage
+2 centigrade to +8 centigrade
Molecular Formula
C6H6Br6
Chemical Name
1,2,3,4,5,6-Hexabromocyclohexane