Description
Glyoxalase I is universally expressed and involved in the protection against cellular damage due to cytotoxic metabolites such as advanced glycation end products (AGEs). It is an integral component of the detoxification system, catalyzing the conversion of reactive, acyclic a-oxoaldehydes into the corresponding a-hydroxyacids in a glutathione-dependent manner.
Abbr
Glx I, Recombinant (Human)
Form
Glyoxalase-1 solution containing 20 mM Tris pH-8, 1mM DTT and 10% glycerol.
Enzyme Commission Number
EC 4.4.1.5
Molecular Weight
20.7 kDa
Unit Definition
One unit will form 1.0 umol of S-lactoylglutathione from methylglyoxal and reduced glutathione per minute at pH 7.5.
Storage
Glyoxalase-I Human Recombinant although stable at 4 °C for weeks, should be stored desiccated below -18 °C. Please prevent freeze/thaw cycles.
Synonyms
lactoylglutathione lyase; EC 4.4.1.5; methylglyoxalase; aldoketomutase; ketone-aldehyde mutase; glyoxylase I; (R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing); 9033-12-9
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