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Docetaxel (Taxotere)
Cat No.
CEI-0274
Description
Docetaxel (Taxotere) can inhibit microtubule disassembly with IC50 of a range of 0.31-100 nM.
CAS No.
114977-28-5
Molecular Weight
807.88
Purity
>99%
Storage
2 years at -20centigrade Powder
Targets
microtubule disassembly
Molecular Formula
C43H53NO14
Chemical Name
Benzenepropanoic acid, beta-[[(1,1-dimethylethoxy)carbonyl]amino]-alpha-hydroxy-, (2aR,4S,4aS,6R,9S,11S,12S,12aR,12bS)-12b-(acetyloxy)-12-(benzoyloxy)-2a,3,4,4a,5,6,9,10,11,12,12a,12b-dodecahydro-4,6,11-trihydroxy-4a,8,13,13-tetramethyl-5-oxo-7,11-methano
Solubility
DMSO 162 mg/mL Water
In vitro
Docetaxel (Taxotere) is a semi-synthetic, second-generation taxane, with anti-neoplastic application for the treatment of breast, ovarian, and non-small cell lung cancer.Docetaxel binds to and stabilizes tubulin, thereby inhibiting microtubule disassembly which results in cell- cycle arrest at the G2/M phase and cell death. The overall cells mean IC50 for docetaxel treatment was 4.67 nM,similar to IC50 values observed across the NCI60 panel of human tumor cell lines.
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