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Cambinol
Cat No.
CEI-0648
Description
An inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC50 = 56 µM) and SIRT2(IC50 = 59 µM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with Cambinol induces apoptosis accompanied by hyperacetylation of BCL6 and p53.
Alias
NSC-112546
Appearance
Off-white solid
Product Overview
A SIRT1 inhibitor
CAS No.
14513-15-6
Molecular Weight
403.52
Purity
>90% by HPLC
Storage
-20 centigrade
Synonyms
NSC-112546
Targets
SIRT1
Molecular Formula
C₂₁H₁₆N₂O₂S
Chemical Name
5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one
Solubility
DMSO
Shipping Conditions
Gel pack
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