Description
HGPRT is a highly active enzyme that catalyzes the reversible transfer of the 5-phosphoribosyl group between α-D-5-phosphoribosyl-1-pyrophosphate (PRPP) and a purine base (hypoxanthine or guanine) to form a purine nucleotide IMP or GMP. The enzyme has been characterized for its affinity for natural substrates and velocity in forward and reverse directions.
Abbr
HGPRT, Recombinant (Human)
Enzyme Commission Number
EC 2.4.2.8
Activity
> 1 Unit/mg protein
Unit Definition
One unit of hypoxanthine-guanine phosphoribosyl transferase converts 1 µmole of hypoxanthine to IMP per minute at pH 8.8 at 25°C.
Storage
HPRT enzyme is provided in lyophilized form and should be stored at –20°C.
Synonyms
Hypoxanthine phosphoribosyltransferase; HGPRTase; HPRT; Hypoxanthine-guanine phosphoribosyltransferase; HGPRT; EC 2.4.2.8
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