GSK1016790A

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Cat No.

COEC-115

Description

GSK1016790A is a novel and potent TRPV4 channel agonist. The TRPV4 (transient receptor potential vanilloid 4) member of the TRP superfamily has been implicated in numerous physiological processes. GSK1016790A elicited Ca2+ influx in mouse and human TRPV4 expressing HEK cells (EC50 values of 18 and 2.1 nM, respectively), and evoked a dose-dependent activation of TRPV4 whole-cell currents at concentrations above 1 nM. It is 300 fold more potent than 4a-PDD.

Applications

A novel and potent TRPV4 channel agonist

Form

Solid

CAS_No

942206-85-1

Molecular Weight

655.61

Purity

≥98%

Synonyms

(N-((1S)-1-{[4-((2S)-2-{[(2,4-Dichlorophenyl)sulfonyl]amino}-3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide

Molecular Formula

C28H32Cl2N4O6S2

Solubility

Soluble in DMSO >10 mg/mL

Refractive Index

1.53 (Predicted)

Density

1.12 g/cm3 (Predicted)

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Our Products Cannot Be Used As Medicines Directly For Personal Use.

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