Treating Hyperuricemia with Nanozymes

It is well known that hyperuricemia is caused by the overexpression of uric acid (UA) in plasma, which can induce many related diseases, such as arthritis, cardiovascular diseases, diabetes, etc. In particular, hyperuricemia promotes the development of gout, resulting in acute and chronic inflammatory arthritis. Although several drugs have been used to treat hyperuricemia and gout, they only relieve symptoms and do not fundamentally cure hyperuricemia, as they lack the ability to dissolve and eliminate existing UA. Therefore, there is an urgent need to develop new enzyme delivery systems with robust stability, long circulation, good efficacy and few side effects for the treatment of hyperuricemia.

Enzyme replacement therapy is a promising approach for the treatment of hyperuricemia. Creative Enzymes is a trusted provider of quality services in antithrombosis with nanozymes. Our platform is equipped with state-of-the-art facilities and highly experienced staff to assist in all areas of nanozyme programs. We guarantee to deliver results on time for our customers.

Hyperuricemia Treatment with Pt Nanozymes

• Since uricase can catalyze the breakdown of uric acid, uricase-based therapy would effectively reduce uric acid levels in plasma although promising, the poor stability of the enzyme and the toxic byproduct H₂O₂ may strongly limit its practical application.
• Creative Enzymes constructs a novel artificial metalize based enzyme replacement therapy (ERT) in which uricase and platinum nanozymes are tightly bound in mesoporous silica nanoparticles.
• These artificial metalloenzymes are used in the treatment of hyperuricemia due to their remarkable self-protective and toxic self-cleaning ability. In addition, they are highly resistant to pH, high temperature, protease, and other damage.

Hyperuricemia Treatment with Fe-N4 Nanozymes

• We use nanozymes to design an artificial peroxisome to accommodate a variety of enzyme-like activities, mimicking the enzymes in native peroxisomes.
• Fe-N4 coordination and atomic iron clusters are formed by doping iron and nitrogen to introduce the enzyme active site into the graphitized portion of the hollow carbon nanozyme shell. The carbon nanozyme exhibited stable and diverse peroxisome-like activities, including catalase, uricase, superoxide dismutase, peroxidase and oxidase.

Fig. 1 Schematic illustration of the design of an artificial peroxisome for ameliorating hyperuricemia using an iron-doped enzyme.

• The nanozymes utilize the tandem activity of uricase-catalase and superoxide dismutase-catalase to treat hyperuricemia and protect free radicals.

Hyperuricemia Treatment with Pd / Ru Nanozyme

• We prepare a novel highly active two-dimensional Pd / Ru nanozymes integrated with uricase for the treatment of hyperuricemia.

Fig. 2 Schematic illustration of the Pd / Ru navigator construction procedure and its treatment for hyperuricemia. (Ming J, et al., 2021)

• The nanoreactor can effectively use uricase to degrade uric acid to produce allantoin and H₂O₂, and use Pd / Ru nanozymes with catalase-like activity to remove H₂O₂. It is not only stable against extreme pH, temperature and proteolytic degradation, but also has a long cycle half-life and good safety.

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