Nanozymes-Based Detection Services

The traditional methods of colorimetry, fluorescence and electrochemical detection to quantify the measured components, which are based on the corresponding signal changes of the reaction system, have been widely used in the detection of biomolecules. Nanozymes have attracted much attention in recent years because of their unique enzymatic catalytic properties. Nanozymes, mainly peroxidase-like substances, can catalyze colored reactions. On this basis, a novel biosensor based on nanozymes has been successfully designed for the detection of ions, small molecules, nucleic acids, proteins, etc.

Creative Enzymes, as a leading global company, is committed to helping our customers achieve effective and successful research. We provide accurate, convenient and guaranteed detection of ion, molecular, nucleic acid, protein services as well as immunoassay services based on nanozymes. In addition, we deliver reliable results and reports on time to our customers all over the world.

Nanozyme-Based Ion Detection Service

• Heavy metals are cofactors of many enzymes, which play an important role in human health, but their content is low. However, excessive intake of heavy metals from environmental pollution poses a serious threat to human life and can cause many life-threatening diseases. Some heavy metal ions have a serious impact on the environment, so it is imperative to monitor the content of heavy metals in the environment.

Fig. 1 Nanozyme-based colorimetric platform for Hg²⁺ detection.

• Furthermore, nanozymes can also be used to detect nonmetal ions such as cyanide ion (CN⁻), F^- and others.

Nanozyme-Based Molecular Detection Services

• The detection of H₂O₂ is applied widely in the food industry, biochemistry, medicine, and environmental protection. Recently, we have established a colorimetric detection strategy based on nanozymes.
• We also provide nanozymes that can achieve the detection of glucose when combining glucose oxidase by using their peroxidase-like ability.
• Glutathione is an endogenous bio thiol involved in redox balance, signaling, gene regulation and other life processes. The abnormal expression of GSH can lead to a series of diseases, and it is very important to detect GSH levels effectively. Creative Enzymes provides detection of GSH services based on types of nanozymes.

Nanozyme-Based Nucleic Acid Detection Services

A variety of sorts of nanozymes in hybridation with nucleic acids and enzymes were able to detect DNA and/or miRNA, some novel hybrid nanozymes are engineered to detect sequence specific nucleic acids, protein aptamers, etc.

Nanozyme-Based Protein Detection Services

Nanozymes based on the inherent peroxidase-like property, by combining H₂O₂ and TMB, can detect protein such as C-reactive protein (CRP), carcino-embryonic antigen, immunodetection of human prostate surface antigen and integrin GPIIb / IIIa on human erythroleukemia cell line. They have a wide range of applications in biomedicine and disease diagnosis.

Nanozyme-Based Immunoassay Services

• The immunoassay has three functions simultaneously: target capture, magnetic separation and color development of the nanozyme for target detection. We offer rapid, high-throughput tests for biomolecules, influenza and Ebola viruses, and chemical contaminants.
• Peroxidase nanozymes catalyze the oxidation of colorimetric substrates to give a color reaction that can be used for visualizing the recognized biomarkers within tissue sections for pathological disease diagnosis and therapeutic monitoring.

Creative Enzymes is always devoted to providing high-quality and satisfactory service to our customers. If you are interested in our services or have some questions, please feel free to contact us or make an online inquiry.