Nanozyme-Based Disease Diagnosis and Treatment

Nanozymes with properties similar to natural enzymes have attracted great interest because of their high stability, easy preparation and excellent catalytic properties. With the rapid development of nanoscience and nanotechnology, the development and application of new nanozymes is unstoppable. Nanozymes have shown great potential in biomedical research, such as bioanalysis, nano imaging, disease diagnosis, drug delivery, cancer treatment, gene therapy and so on. In addition, nanozymes have good biocompatibility, excellent photo-stability, highly selective and real-time detection of disease markers, which is expected to become an ideal material for disease diagnosis and treatment.

Creative Enzymes, as a leading global company, is committed to helping our customers achieve effective and successful research. We provide disease diagnosis and treatment based on nanozymes. In addition, we deliver reliable results and reports on time to our customers all over the world.

Virus Detection and Antiviral Therapy with Nanozymes

• Viruses are also a large group of pathogenic microorganisms that threaten human safety. In the early stage of the outbreak, the rapid development of efficient virus detection methods and the development of new antiviral drugs are critical to timely control the spread of the epidemic.

Fig. 1 Illustration of the synthesis of Cur-CPDs and their antiviral applications.

• The existing virus molecular biology detection techniques are mainly divided into two categories, nucleic acid detection and protein detection. With the progress of nanotechnology, some nanoparticles with antiviral activity, such as metal nanoparticles, inorganic nanoparticles and GO, have been reported.

Inflammation Treatment with Nanozymes

• Inflammation is closely related to abnormal production of reactive oxygen species in the body.
• Therefore, the development of nanozymes with a variety of nanozyme activities that can effectively remove multiple reactive oxygen species at the same time is expected to play a potential application value in the field of inflammation therapy. However, current studies have focused on metal-doped nanoparticles.

Neurodegenerative Disease Treatment with Nanozymes

• Nanozymes have been paid great attention to neuroprotection because of their antioxidant enzyme activity, which can efficiently remove ROS. During ischemia, ROS production and accumulation cause oxidative damage, leading to ischemic damage and stroke-related cell death.
• Creative Enzymes develops types of nanozymes which can eliminate ROS in the body to prevent ischemic stroke.

Antithrombosis with Nanozymes

• Thrombosis is one of the most common and serious problems that cause complications of blood upon contacting with biomedical devices.
• Glucose oxidase can catalyze endogenous glucose to produce H₂O₂. Then, we establish nitric oxide synthase mimics to further catalyze the oxidation of L-arginine to produce anti-thrombotic HNO under the assistance of H₂O₂ in the physiological environment.

Anti-Tumor Formation with Nanozymes

• Radiotherapy, chemotherapy and surgical resection are still the main cancer treatment strategies, but there are still strong side effects of these treatments. Therefore, it is very important to find new safe and efficient tumor treatment strategies.

Fig. 2 Pt nanozyme loaded BP nanosheets for tumor photodynamic therapy.

• Regulating the balance between hypoxia and ROS may lead to tumor cell death. The types of nanozymes we establish can induce oxidative stress to kill tumor cells by generating ROS through OXD and POD activities, and can also relieve tumor tissue hypoxia and induce tumor cell death.

Treating Hyperuricemia with Nanozymes

• Hyperuricemia, caused by abnormally high levels of uric acid (UA) in serum, has been reported to be associated with diseases such as gout, metabolic syndrome, hypertension, diabetes, kidney stones, and cardiovascular diseases.
• Nanozymes not only have enzyme-like activity to generate or exclude reactive oxygen species (ROS), but also can combine with enzymes for cascade catalysis. We construct an innovative nanozymes-uricase cascade system for the treatment of hyperuricemia.

Diseases Imaging with Nanozymes

• Nanozymes have unique physicochemical properties, such as luminescence, X-ray absorption, and paramagnetic.
• With unique physicochemical properties and enzyme-like catalytic activity, nanozymes have been widely developed in disease imaging and detection, and may have good application prospects in precision medicine.

Creative Enzymes is always devoted to providing high-quality and satisfactory service to our customers. If you are interested in our services or have some questions, please feel free to contact us or make an online inquiry.