Inflammation Treatment with Nanozymes

Inflammation is the body's defensive response to stimuli. It usually manifests as redness, fever, pain and dysfunction. Inflammation is often a precursor to many diseases, so it is important to treat it in time. Many studies have reported that the over-expression of reactive oxygen species can be regarded as an important indicator of inflammatory response. Therefore, scavenging expressed ROS can alleviate inflammation and inhibit the occurrence of related diseases.

Creative Enzymes develops an advanced platform that provides services to customers worldwide covering inflammation treatment with nanozymes. We customize featured services according to customer needs with decades of experience in nanozymes. In addition, we deliver satisfactory and reliable results and reports on time to our customers around the world.

Inflammation Treatment with Prussian Blue Nanozyme

• ROS scavenging property of Prussian blue (PB) nanozymes is due to their affinity for hydroxyl radicals and their ability to mimic three enzymes, superoxide dismutase, catalase, and peroxidase.

Fig. 1 Multienzyme-like properties of PB nanoparticles in vitro.

• Creative Enzymes develops Prussian blue nanozymes, with multienzyme-like properties, which can effectively decrease intracellular ROS level and achieve excellent cyto-protection efficiency.
• PB nanozymes exhibit anti-inflammatory effects on mice hepatitis model in vivo. These results demonstrate their unique features in ROS-induced inflammatory or injury.

Inflammation Treatment with V₂O₅@pDA@MnO₂ Nanozyme

• In living systems, enzymes are not always working alone, and many enzymes may participate in the same life process.

Fig. 2 V₂O₅@pDA@MnO₂ nanozyme system to mimic intracellular antioxidant enzyme-based defense system.

• Creative Enzymes constructs a powerful multi nanozyme-based composite to mimic enzyme-based antioxidant defense system, which can remove expressed ROS effectively and protect the body against oxidative damage.
• We use V₂O₅ and MnO₂ as nanozyme models. V₂O₅ nanowires have similar activity to GPx and can effectively catalyze the decomposition of H₂O₂ into non-toxic products. Meanwhile, MnO₂ nanoparticles simultaneously have similar catalytic properties as SOD and CAT. Therefore, V₂O₅@pDA@MNO₂ nano-complex with polydopamine (pDA) has the function of a variety of antioxidant enzymes, which can effectively simulate the intracellular antioxidant defense process jointly participated by SOD, CAT and GPx.
• Thus, by combining the antioxidative abilities of nanozymes and pDA, the V₂O₅@pDA@MNO₂ nanocomposites exhibit a synergistic ROS scavenging effect, that can protect cell components against oxidative damage.

Inflammation Treatment with Cerium Oxide Nanozyme

• Cerium oxide (CeO₂) nanozymes have similar activities as superoxide dismutase and catalase, which can effectively remove the overexpressed ROS in cells and alleviate a series of inflammatory reactions caused by ROS.
• We add Zr⁴⁺ into CeO₂ nanozymes to prepare composite nanoparticles. The introduction of Zr⁴⁺ effectively controls the ratio of Ce³⁺ / Ce⁴⁺ and the conversion between the two oxidation states to improve the antioxidant capacity of the nano-complex.
• Therefore, it can effectively reduce the content of reactive oxygen species and reactive nitrogen in the inflammatory site, relieve the inflammatory reaction, and protect the body from oxidative damage.

Creative Enzymes offers professional services covering inflammation treatment with nanozymes to meet your research needs. With years of experience in nanozymes, our advanced platforms can help our clients solve various difficulties and conduct research. If you are interested in our services or have any questions, please feel free to contact us or make an online inquiry.